Real-time fingerprint of the bio-system

The bioprocess system (bacterial, yeast/ fungal, mammalian cells) behaves as a colloid suspension undergoing physicochemical changes upon growth, such as:

• Bio-particle cross-linking (cell clumping, aerial mycelium formation in filamentous)

• Cultures, extra-cellular polymer formation, apoptosis

• Protein aggregation (antibodies) foaming
  

 

These changes can be described in terms of properties such as density, volume fraction, shear modules and radius of the bio-particles.

 

Our software sensor provides a profile as a characteristic fingerprint of the dynamic bioculture.

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